A vaccine for the Rift Valley fever virus based on polymer nanoparticles has appeared.
Scientists from the Mendeleev Russian University of Chemical Technology (RCTU) under the leadership of Professor Mikhail Shtilman, together with colleagues from the Vector Center and other Russian scientists, have created polymer nanoparticles that can carry poorly soluble biologically active substances through the body.
Today pharmacists can offer you tablets and gelatin capsules, these forms of drug delivery partially solve the problem of insoluble drugs, but they are not safe and effective enough. Therefore, scientists are developing methods for targeted delivery of drugs to the desired organs and tissues using various carriers, in particular, nanoparticles.
The authors of the new work presented their way of creating a drug that can pass through the blood-brain barrier – the barrier between the circulatory system and the central nervous system.
The authors tested their algorithm for creating nanoparticles using the example of the virus that causes Rift Valley fever. This disease is common in Africa and affects mainly animals, but can also spread to humans. He has a low mortality rate, but in the course of the disease, damage to the liver, retina and other neurological complications may begin.
In addition, vectors, some specific proteins to bind to certain cells in the body, or something else can be added to the shell of the nanoparticle, which would increase the effectiveness of the carrier. Thus, it is possible to provide targeted delivery of the drug or supplement it, for example, with water-soluble active substances that the amphiphilic polymer molecule cannot take inside.
Andrey Kuskov, Head of the Department of Technology of Chemical, Pharmaceutical and Cosmetic Products, Russian Chemical Technology University
The authors note that their nanoparticles can be made as a universal drug delivery method.